免疫学
免疫球蛋白E
屋尘螨
抗原提呈细胞
抗原
CD40
过敏原
嗜酸性粒细胞增多症
T细胞
B细胞
生物
免疫系统
抗体
医学
过敏
细胞毒性T细胞
体外
生物化学
作者
Mélissa Dullaers,Martijn J. Schuijs,Monique Willart,Kaat Fierens,Justine Van Moorleghem,Hamida Hammad,Bart N. Lambrecht
标识
DOI:10.1016/j.jaci.2016.09.020
摘要
Allergic asthma is a CD4 TH2-lymphocyte driven disease characterized by airway hyperresponsiveness and eosinophilia. B cells can present antigens to CD4 T cells and produce IgE immunoglobulins that arm effector cells; however, mouse models are inconclusive on whether B cells are necessary for asthma development.We sought to address the role of B cells in a house dust mite (HDM)-driven TH2-high asthma mouse model.Wild-type and B cell-deficient muMT mice were sensitized and challenged through the airways with HDM extracts. The antigen-presenting capacities of B cells were studied by using new T-cell receptor transgenic 1-DER mice specific for the Der p 1 allergen.In vitro-activated B cells from HDM-exposed mice presented antigen to 1-DER T cells and induced a TH2 phenotype. In vivo B cells were dispensable for activation of naive 1-DER T cells but necessary for full expansion of primed 1-DER T cells. At high HDM challenge doses, B cells were not required for development of pulmonary asthmatic features yet contributed to TH2 expansion in the mediastinal lymph nodes but not in the lungs. When the amount of challenge allergen was decreased, muMT mice had reduced asthma features. Under these limiting conditions, B cells contributed also to expansion of TH2 effector cells in the lungs and central memory T cells in the mediastinal lymph nodes.B cells are a major part of the adaptive immune response to inhaled HDM allergen, particularly when the amount of inhaled allergen is low, by expanding allergen-specific T cells.
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