癌症
阶段(地层学)
癌症研究
生物标志物
胃切除术
生存分析
比例危险模型
作者
Yan Zhang,Jin Li,Jiang Yu,Hao Liu,Zhiyong Shen,Gentai Ye,Tingyu Mou,Xiaolong Qi,Guoxin Li
出处
期刊:Oncotarget
[Impact Journals, LLC]
日期:2017-02-11
卷期号:8 (14): 22936-22943
被引量:53
标识
DOI:10.18632/oncotarget.15288
摘要
Tumor recurrence is usually detected within one year after radical resection of stage III gastric cancer. This study aimed to establish the expression profile and determine potential circular RNAs (circRNAs) and predict the early recurrence of stage III gastric cancer. We identified 46 differently expressed circRNAs between cancer and adjacent normal tissues through circRNA microarray. We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from those with a low risk. The areas under the receiver operator characteristic curve (ROC) of this classifier were 0.763 and 0.711 in the two cohorts, respectively. A new formula could be established by combined the circRNA classifier with TNM stages. The areas under the ROC curve were 0.866 and 0.818 of the two cohorts, respectively. Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery.
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