材料科学
伤口愈合
辣根过氧化物酶
自愈水凝胶
组织工程
儿茶酚
胶粘剂
生物污染
生物物理学
纳米技术
生物医学工程
生物化学
高分子化学
化学
生物
酶
免疫学
医学
图层(电子)
膜
作者
Rui Wang,Jing-Zhe Li,Wei Chen,Tingting Xu,Shifeng Yun,Zheng Xu,Zongqi Xu,Takashi Sato,Bo Chi,Hong Xu
标识
DOI:10.1002/adfm.201604894
摘要
In situ hydrogels have attracted considerable attention in tissue engineering because of their minimal invasiveness and ability to match the irregular tissue defects. However, hydrous physiological environments and the high level of moisture in hydrogels severely hamper binding to the target tissue and easily cause wound infection, thereby limiting the effectiveness in wound care management. Thus, forming an intimate assembly of the hydrogel to the tissue and preventing wound infecting still remains a significant challenge. In this study, inspired by mussel adhesive protein, a biomimetic dopamine‐modified ε‐poly‐ l ‐lysine‐polyethylene glycol‐based hydrogel (PPD hydrogel) wound dressing is developed in situ using horseradish peroxidase cross‐linking. The biomimetic catechol–Lys residue distribution in PPD polymer provides a catechol–Lys cooperation effect, which endows the PPD hydrogels with superior wet tissue adhesion properties. It is demonstrated that the PPD hydrogel can facilely and intimately integrate with biological tissue and exhibits superior capacity of in vivo hemostatic and accelerated wound repair. In addition, the hydrogels exhibit outstanding anti‐infection property because of the inherent antibacterial ability of ε‐poly‐ l ‐lysine. These findings shed new light on the development of mussel‐inspired tissue‐anchored and antibacterial hydrogel materials serving as wound dressings.
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