胰岛素
生物
脂肪组织
胰岛素受体
受体
细胞生物学
内科学
内分泌学
亚科
生物化学
胰岛素抵抗
基因
医学
作者
Renald Delanoue,Eleonora Meschi,Neha Agrawal,Alessandra Mauri,Yonit Tsatskis,Helen McNeill,Pierre Léopold
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-09-30
卷期号:353 (6307): 1553-1556
被引量:137
标识
DOI:10.1126/science.aaf8430
摘要
Animals adapt their growth rate and body size to available nutrients by a general modulation of insulin–insulin-like growth factor signaling. In Drosophila , dietary amino acids promote the release in the hemolymph of brain insulin-like peptides (Dilps), which in turn activate systemic organ growth. Dilp secretion by insulin-producing cells involves a relay through unknown cytokines produced by fat cells. Here, we identify Methuselah (Mth) as a secretin-incretin receptor subfamily member required in the insulin-producing cells for proper nutrient coupling. We further show, using genetic and ex vivo organ culture experiments, that the Mth ligand Stunted (Sun) is a circulating insulinotropic peptide produced by fat cells. Therefore, Sun and Mth define a new cross-organ circuitry that modulates physiological insulin levels in response to nutrients.
科研通智能强力驱动
Strongly Powered by AbleSci AI