Association of cognitive impairment and breast cancer survivorship on quality of life in younger breast cancer survivors

医学 生活质量(医疗保健) 乳腺癌 生存曲线 口语流利性测试 神经心理学 认知 心理干预 临床心理学 言语记忆 萧条(经济学) 癌症 精神科 内科学 宏观经济学 护理部 经济
作者
Diane Von Ah,Adele Crouch,Patrick O. Monahan,Timothy E. Stump,Frederick W. Unverzagt,Susan Storey,Andrea A. Cohee,David Cella,Victoria L. Champion
出处
期刊:Journal of Cancer Survivorship [Springer Nature]
卷期号:16 (4): 812-822 被引量:15
标识
DOI:10.1007/s11764-021-01075-x
摘要

Younger breast cancer survivors (BCS) often report cognitive impairment and poor quality of life (QoL), which could be interrelated. The purpose of this study was to examine the association of cognitive impairment and breast cancer status (BCS versus healthy control (HC)), with QoL, which included psychological (depressive symptoms, well-being, perceived stress, and personal growth) and physical well-being (physical functioning and fatigue).Four hundred ninety-eight BCS (≤45 years at diagnosis) who were 3 to 8 years post-chemotherapy treatment and 394 HC completed subjective questionnaires and a one-time neuropsychological assessment, including tests of attention, memory, processing speed, and verbal fluency. For each test, cognitive impairment was defined as scoring 1.5 and 2.0 standard deviations below the mean of the HC group. Separate linear regression models for each outcome were ran controlling for known covariates.BCS reported significantly more memory problems than HC (p < 0.0001), with up to 23% having significant impairment. Cognitive performance did not differ significantly between BCS and HCs. BCS vs. HCs had greater depression and fatigue, yet more personal growth. Objective and subjective cognitive impairment were significantly related to greater depressive symptoms and perceived stress and lower well-being and physical functioning; whereas, objective impairment was related to less personal growth and subjective impairment was related to greater fatigue.Younger BCS report significant cognitive impairment years after treatment which may relate to greater decrements in QoL.Assessment and interventions to address cognitive concerns may also influence QoL outcomes in younger BCS.
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