亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Associations between plasma fatty acid concentrations and schizophrenia: a two-sample Mendelian randomisation study

孟德尔随机化 脂肪酸 精神分裂症(面向对象编程) 医学 遗传学 生物 化学 基因 精神科 生物化学 遗传变异 基因型
作者
Hannah Jones,Maria Carolina Borges,Rebecca Carnegie,David Mongan,Peter J. Rogers,Sarah J. Lewis,Andrew Thompson,Stanley Zammit
出处
期刊:The Lancet Psychiatry [Elsevier]
卷期号:8 (12): 1062-1070 被引量:57
标识
DOI:10.1016/s2215-0366(21)00286-8
摘要

Although studies suggest that concentrations of omega-3 and omega-6 fatty acids are lower in individuals with schizophrenia, evidence for beneficial effects of fatty acid supplementation is scarce. Therefore, in this study, we aimed to determine whether omega-3 and omega-6 fatty acid concentrations are causally related to schizophrenia.We did a two-sample Mendelian randomisation study, using deidentified summary-level data that were publicly available. Exposure-outcome relationships were evaluated using the inverse variance weighted two-sample Mendelian randomisation method using results from genome-wide association studies (GWASs) of fatty acid concentrations and schizophrenia. GWAS results were available for European (fatty acids) and European and Asian (schizophrenia) ancestry samples. Overall age and gender information were not calculable from the summary-level GWAS results. Weighted median, weighted mode, and Mendelian randomisation Egger regression methods were used as sensitivity analyses. To address underlying mechanisms, further analyses were done using single instruments within the FADS gene cluster and ELOVL2 gene locus. FADS gene cluster and ELOVL2 gene causal effects on schizophrenia were calculated by dividing the single nucleotide polymorphism (SNP)-schizophrenia effect estimate by the SNP-fatty acid effect estimate with standard errors derived using the first term from a delta method expansion for the ratio estimate. Multivariable Mendelian randomisation was used to estimate direct effects of omega-3 fatty acids on schizophrenia, independent of omega-6 fatty acids, lipoproteins (ie, HDL and LDL), and triglycerides.Mendelian randomisation analyses indicated that long-chain omega-3 and long-chain omega-6 fatty acid concentrations were associated with a lower risk of schizophrenia (eg, inverse variance weighted odds ratio [OR] 0·83 [95% CI 0·75-0·92] for docosahexaenoic acid). By contrast, there was weak evidence that short-chain omega-3 and short-chain omega-6 fatty acids were associated with an increased risk of schizophrenia (eg, inverse variance weighted OR 1·07 [95% CI 0·98-1·18] for α-linolenic acid). Effects were consistent across the sensitivity analyses and the FADS single-SNP analyses, suggesting that long-chain omega-3 and long-chain omega-6 fatty acid concentrations were associated with lower risk of schizophrenia (eg, OR 0·74 [95% CI 0·58-0·96] for docosahexaenoic acid) whereas short-chain omega-3 and short-chain omega-6 fatty acid concentrations were associated with an increased risk of schizophrenia (eg, OR 1·08 [95% CI 1·02-1·15] for α-linolenic acid). By contrast, estimates from the ELOVL2 single-SNP analyses were more imprecise and compatible with both risk-increasing and protective effects for each of the fatty acid measures. Multivariable Mendelian randomisation indicated that the protective effect of docosahexaenoic acid on schizophrenia persisted after conditioning on other lipids, although evidence was slightly weaker (multivariable inverse variance weighted OR 0·84 [95% CI 0·71-1·01]).Our results are compatible with the protective effects of long-chain omega-3 and long-chain omega-6 fatty acids on schizophrenia, suggesting that people with schizophrenia might have difficulty converting short-chain polyunsaturated fatty acids to long-chain polyunsaturated fatty acids. Further studies are required to determine whether long-chain polyunsaturated fatty acid supplementation or diet enrichment might help prevent onset of schizophrenia.National Institute for Health Research Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jiangjiang完成签到 ,获得积分10
18秒前
吱吱草莓派完成签到 ,获得积分10
23秒前
51秒前
小二郎应助科研通管家采纳,获得10
51秒前
56秒前
1分钟前
宝贝丫头完成签到 ,获得积分10
1分钟前
英姑应助背后的鞋垫采纳,获得10
1分钟前
桐桐应助Benhnhk21采纳,获得10
1分钟前
Dave发布了新的文献求助10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
Aaron完成签到 ,获得积分0
3分钟前
3分钟前
5分钟前
Liufgui应助Dave采纳,获得10
5分钟前
Benhnhk21发布了新的文献求助10
5分钟前
yydragen应助yyds采纳,获得10
5分钟前
Hisam完成签到,获得积分10
5分钟前
lhy完成签到,获得积分10
6分钟前
lhy发布了新的文献求助10
6分钟前
6分钟前
积极的台灯应助Benhnhk21采纳,获得10
6分钟前
Hisam发布了新的文献求助10
6分钟前
yyds完成签到,获得积分0
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
木木完成签到 ,获得积分10
6分钟前
7分钟前
董可以发布了新的文献求助10
7分钟前
小马甲应助董可以采纳,获得10
7分钟前
7分钟前
Boren发布了新的文献求助10
7分钟前
梨子完成签到,获得积分10
7分钟前
Boren完成签到,获得积分10
7分钟前
WerWu完成签到,获得积分10
9分钟前
彭于晏应助Dc采纳,获得10
9分钟前
10分钟前
情怀应助科研通管家采纳,获得10
10分钟前
11分钟前
Dc发布了新的文献求助10
11分钟前
Dc完成签到,获得积分10
11分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990290
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805197
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234