肺癌
医学
癌症
癌症研究
细胞凋亡
脂质过氧化
肺癌的治疗
癌细胞
生物信息学
病理
氧化应激
内科学
生物
生物化学
作者
Sikai Wu,Chengchu Zhu,Daolin Tang,Q. Ping Dou,Jianfei Shen,Xin Chen
标识
DOI:10.1186/s40364-021-00338-0
摘要
Abstract Lung cancer is one of the most common cancers in the world. Although medical treatment has made impressive progress in recent years, it is still one of the leading causes of cancer-related deaths in men and women. Ferroptosis is a type of non-apoptotic cell death modality, usually characterized by iron-dependent lipid peroxidation, rather than caspase-induced protein cleavage. Excessive or lack of ferroptosis is associated with a variety of diseases, including cancer and ischaemia-reperfusion injury. Recent preclinical evidence suggests that targeting ferroptotic pathway is a potential strategy for the treatment of lung cancer. In this review, we summarize the core mechanism and regulatory network of ferroptosis in lung cancer cells, and highlight ferroptosis induction-related tumor therapies. The reviewed information may provide new insights for targeted lung cancer therapy.
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