光动力疗法
光敏剂
荧光
体内
光毒性
化学
量子产额
光化学
接受者
荧光寿命成像显微镜
生物物理学
体外
生物化学
光学
有机化学
生物
物理
生物技术
凝聚态物理
作者
Huang Li,Deyan Qing,Shaojing Zhao,Xiaoli Wu,Ke Yang,Xiaojie Ren,Xiuli Zheng,Minhuan Lan,Jun Ye,Lintao Zeng,Guangle Niu
标识
DOI:10.1016/j.cej.2021.132638
摘要
Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high 1O2 generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.
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