化学
烷基
电泳剂
芳基
部分
催化作用
酰胺
有机硅
酮
药物化学
乙醚
溴化物
有机化学
高分子化学
偶联反应
硅烷化
作者
Jingui Duan,Yuquan Wang,Liangliang Qi,Peng Guo,Xiaoyang Pang,Xing‐Zhong Shu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-10-05
卷期号:23 (20): 7855-7859
被引量:32
标识
DOI:10.1021/acs.orglett.1c02874
摘要
Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp3)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alcohol, ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R2 moiety into complex molecules and the immobilization of a glass surface by formed organosilanes were demonstrated.
科研通智能强力驱动
Strongly Powered by AbleSci AI