医学
败血症
重症监护医学
维生素D与神经学
内科学
维生素
作者
Stefan Müller,Thomas Wiesmann,Hinnerk Wulf,Christian Arndt
出处
期刊:Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie
[Georg Thieme Verlag]
日期:2021-05-01
卷期号:56 (5): 374-382
摘要
Vitamin C deficiency often occurs in critical illness and especially in patients with sepsis. Low plasma levels correlate with organ dysfunction and outcome parameters. Vitamin C offers pleiotropic effects possibly attenuating pathophysiology in sepsis. This includes antioxidative effects like scavenging reactive oxygen species or restoring other antioxidants. Vitamin C is a cofactor for norepinephrine biosynthesis and it protects endothelial function. In addition, it modulates immune response. A combined therapy with vitamin C, hydrocortisone and thiamine could be beneficial because of synergistic effects. Some clinical studies have shown reduced mortality due to vitamin C alone or in combination with hydrocortisone and thiamine, others do not. Adverse events are rare. So data supporting a therapy with vitamin C is still unclear. Further randomised controlled trials are necessary.
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