Promotion of the anticancer activity of curcumin based on a metal–polyphenol networks delivery system

姜黄素 生物利用度 化学 药物输送 多酚 体内 流式细胞术 药理学 细胞凋亡 活性成分 体外 生物化学 抗氧化剂 有机化学 分子生物学 生物技术 生物
作者
Yuanyuan Chen,Die Jia,Qiming Wang,Yueru Sun,Zhenan Rao,Xiaojuan Lei,Jichun Zhao,Kaifang Zeng,Zhigang Xu,Jian Ming
出处
期刊:International Journal of Pharmaceutics [Elsevier]
卷期号:602: 120650-120650 被引量:23
标识
DOI:10.1016/j.ijpharm.2021.120650
摘要

Curcumin (Cur), a hydrophobic active pharmaceutical ingredient with high anticancer activity, has poor water solubility and low bioavailability. Although many delivery systems have been developed to improve their bioavailability, some limitation such as low drug loading efficiency and poor stability are still remained. The metal-polyphenol networks (MPNs) delivery system designed in this subject solved above problems and effectively improved the anticancer activity of Cur. The synthesized [email protected](III) is consisting of epigallocatechin gallate (EGCG), iron chloride (FeCl3) and Cur, and the well-designed structure endow [email protected](III) high loading efficiency, good water solubility and stability. After the [email protected](III) nanoparticles were internalized by MCF-7 cells, the Cur could be released in endo/lysosomal microenvironment (pH = 5.0), and the Cur delivery in the deep tumor could be realized. The distribution of [email protected](III) in MCF-7 cells was analyzed by laser confocal, and [email protected](III) could effectively deliver more Cur into MCF-7 cells in comparison with free Cur. In addition, the results of flow cytometry and western blot further indicated that [email protected](III) had a stronger ability to induce apoptosis than free Cur. Transwell cell migration and invasion experiments showed that Cur and EGCG-Fe(III) had a synergistic effect in inhibiting MCF-7 cell migration and invasion. In vitro hemolysis and in vivo experiments showed that the [email protected](III) had negligible effect on the blood environment and a great tumor-inhibition efficacy, indicating that the MPNs delivery system had a good blood compatibility and antitumor activity. Our results indicated that MPNs-coated Cur nanoparticle could be a new form of Cur delivery system for anticancer application.
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