生物
端粒酶
RNA剪接
端粒酶逆转录酶
细胞生物学
端粒
选择性拼接
拼接因子
端粒酶RNA组分
剪接体
遗传学
癌症研究
基因
标识
DOI：10.1038/s41576-021-00372-6
摘要
Human telomerase reverse transcriptase (hTERT) activity is tightly controlled. This report shows that hTERT is primarily regulated by alternative splicing; skipping of exon 2 triggers decay of TERT mRNA in differentiated cells and its retention promotes telomere maintenance in pluripotent cells.
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清脆松
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tuanheqi
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传奇3
西罗
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genomed
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