环状RNA
小RNA
核糖核酸
生物
机制(生物学)
骨肉瘤
非编码RNA
基因表达
生物信息学
癌症研究
骨质疏松症
基因
细胞生物学
计算生物学
遗传学
内分泌学
哲学
认识论
作者
Wei Huang,Yongyao Wu,Mingxin Qiao,Zhuojun Xie,Xiao Cen,Xinqi Huang,Zhihe Zhao
摘要
Circular RNA (circRNA) is a class of endogenous noncoding RNA (ncRNA), presenting as a special covalent closed loop without a 5' cap or 3' tail, maintaining resistance to RNA exonuclease and keeping high stability. Although lowly expressed in most situations, circRNA makes an active difference in regulating physiological or pathological processes by modulating gene expression by regulation of transcription, protein, and miRNA functions through various mechanisms in particular tissues. Recent studies have demonstrated the roles of the miRNA-circRNA network in the development of several bone diseases such as osteoporosis, a multiple-mechanism disease resulting from defective bone quality and low bone mass, osteoarthritis, whose main pathomechanism is inflammation and articular cartilage degradation, as well as osteosarcoma, known as one of the most common bone cancers. However, the specific mechanism of how circRNA along with miRNA influences those diseases is not well documented, showing potential for the development of new therapies for those bone diseases.
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