医学
四分位数
缬氨酸
内科学
糖尿病
比例危险模型
入射(几何)
体质指数
2型糖尿病
异亮氨酸
内分泌学
置信区间
亮氨酸
氨基酸
生物
光学
物理
生物化学
作者
Bianca de Almeida-Pititto,Patrícia Médici Dualib,Martha C. Jordão,Marília Izar Helfenstein Fonseca,Steven R. Jones,Michael J. Blaha,Peter P. Tóth,Raúl D. Santos,Isabela M Benseñor,Sandra Roberta G. Ferreira,Paulo A. Lotufo
标识
DOI:10.1016/j.diabres.2021.108747
摘要
Aims To evaluate the role of branch chain amino acid (BCAA) concentrations as a predictor for incident type 2 diabetes (DM). Methods Participants from ELSA-Brasil without diabetes at baseline and followed for 3.9 ± 0.6 years were included in the analysis. The determinations of BCAA (valine, leucine, isoleucine) were performed by proton nuclear magnetic resonance spectroscopy. Cardiometabolic profile and incidence of DM were evaluated according to quartiles of BCAA at baseline, stratified by sex. Results From 3,828 participants (56% female, 50.5 ± 8.7 years) 299 (8.5%) were diagnosed with DM. For both sexes, a worsening of cardiometabolic profile was observed across increasing BCAA quartiles. In survival analysis, incidence rates of DM for the entire period were highest in participants in the third and fourth quartile of BCAA (log Rank analysis < 0.001 for both sexes). In Cox regression analysis, for men, the HR (95%CI) for risk of DM was 2.24 (1.24–4.03) for those from the fourth quartile of BCAA, while in women it was 1.94 (1.07–3.50), comparing to first quartile of BCAA after adjustments for age, BMI, physical activity, family history of DM, pre-diabetes, blood pressure, total cholesterol and HOMA-IR. Conclusions Higher levels of BCAA were independently predictors of DM.
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