内部核糖体进入位点
核糖核酸
翻译(生物学)
生物
N6-甲基腺苷
真核翻译
核糖体
病毒学
甲基化
遗传学
信使核糖核酸
DNA
基因
甲基转移酶
作者
Geon Woo Kim,Aleem Siddiqui
标识
DOI:10.1073/pnas.2022024118
摘要
Significance N6-methyladenosine (m 6 A) modification is an emerging topic of RNA biology, and its functional roles are being investigated. m 6 A modification occurs in RNAs cotranscriptionally and regulates RNA stability and translation. m 6 A methylation has been identified in RNA virus genomes and the RNA transcripts of DNA viruses. These m 6 A modifications regulate the viral life cycle in various aspects and pathogeneses associated with individual viral infections. Here, we demonstrated that m 6 A modification of the internal ribosome entry site (IRES) region of the hepatitis C virus (HCV) recruits YTHDC2, which in concert with the cellular La antigen supports the HCV IRES-mediated translation. Our study shows the functional roles of m 6 A modification and YTHDC2 in the IRES-mediated translation.
科研通智能强力驱动
Strongly Powered by AbleSci AI