Genome-Wide Detection of Genetic Loci and Candidate Genes for Body Conformation Traits in Duroc × Landrace × Yorkshire Crossbred Pigs

遗传建筑学 数量性状位点 候选基因 生物 全基因组关联研究 遗传学 基因 单核苷酸多态性 遗传关联 表型 人口 基因型 医学 环境卫生
作者
Hui Zhang,Zhanwei Zhuang,Ming Yang,Rongrong Ding,Jianping Quan,Shenping Zhou,Ting Gu,Zheng Xu,Enqin Zheng,Gengyuan Cai,Jie Yang,Zhenfang Wu
出处
期刊:Frontiers in Genetics [Frontiers Media SA]
卷期号:12 被引量:22
标识
DOI:10.3389/fgene.2021.664343
摘要

The Duroc × (Landrace × Yorkshire) hybrid pigs (DLY) are the most popular commercial pigs, providing consumers with the largest source of pork. In order to gain more insights into the genetic architecture of economically important traits in pigs, we performed a genome-wide association study (GWAS) using the GeneSeek Porcine 50 K SNP Chip to map the genetic markers and genes associated with body conformation traits (BCT) in 311 DLY pigs. The quantitative traits analyzed included body weight (BW), carcass length (CL), body length (BL), body height (BH), and body mass index (BMI). BMI was defined as BMICL, BMIBL, and BMIBH, respectively, based on CL, BL, and BH phenotypic data. We identified 82 SNPs for the seven traits by GEMMA-based and FarmCPU-based GWASs. Both methods detected two quantitative trait loci (QTL) on SSC8 and SSC17 for body conformation traits. Several candidate genes (such as TNFAIP3, KDM4C, HSPG2, BMP2, PLCB4, and GRM5) were found to be associated with body weight and body conformation traits in pigs. Notably, the BMP2 gene had pleiotropic effects on CL, BL, BH, BMICL, and BMIBL and is proposed as a strong candidate gene for body size due to its involvement in growth and bone development. Furthermore, gene set enrichment analysis indicated that most of the pathway terms are associated with regulation of cell growth, negative regulation of cell population proliferation, and chondrocyte differentiation. We anticipate that these results further advance our understanding of the genetic architecture of body conformation traits in the popular commercial DLY pigs and provide new insights into the genetic architecture of BMI in pigs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
对照完成签到 ,获得积分10
刚刚
冷酷的墨镜完成签到,获得积分10
1秒前
3秒前
gouyanju完成签到,获得积分10
3秒前
青蛙的第二滴口水完成签到,获得积分10
4秒前
彭于晏应助shifeng_zai采纳,获得10
6秒前
。。。完成签到,获得积分10
6秒前
端庄谷南发布了新的文献求助10
7秒前
贾苏戏发布了新的文献求助10
8秒前
8秒前
心无杂念完成签到 ,获得积分10
8秒前
YY完成签到,获得积分10
9秒前
雪白的夜香完成签到,获得积分10
11秒前
maox1aoxin应助许多鱼采纳,获得20
11秒前
子夜完成签到,获得积分10
12秒前
13秒前
君临天下完成签到,获得积分10
13秒前
SMG完成签到 ,获得积分10
13秒前
15秒前
tuanheqi应助贾苏戏采纳,获得30
15秒前
Lucy小影完成签到,获得积分10
16秒前
马上动起来完成签到,获得积分10
17秒前
18秒前
醒了没醒醒完成签到,获得积分10
19秒前
酷波er应助zzh0409km采纳,获得10
19秒前
火星上的小蚂蚁完成签到,获得积分10
19秒前
月月发布了新的文献求助10
20秒前
冷傲的薯片应助CXSCXD采纳,获得10
21秒前
皇帝的床帘完成签到,获得积分10
21秒前
研友_LBaRl8完成签到,获得积分10
22秒前
懒大王发布了新的文献求助10
22秒前
23秒前
白色的风车完成签到,获得积分10
24秒前
25秒前
cctv18应助luke采纳,获得10
25秒前
立冬完成签到,获得积分10
26秒前
cctv18应助雪白的夜香采纳,获得10
28秒前
PandaC完成签到,获得积分10
29秒前
打打应助zyyyyyy采纳,获得10
30秒前
翊然甜周完成签到,获得积分10
30秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248917
求助须知:如何正确求助?哪些是违规求助? 2892299
关于积分的说明 8270565
捐赠科研通 2560582
什么是DOI,文献DOI怎么找? 1389114
科研通“疑难数据库(出版商)”最低求助积分说明 651004
邀请新用户注册赠送积分活动 627855