Association between systemic inflammation and activities of daily living disability among Chinese elderly individuals: the mediating role of handgrip strength

日常生活活动 医学 调解 纵向研究 老年学 肌萎缩 联想(心理学) 物理疗法 内科学 心理学 政治学 病理 法学 心理治疗师
作者
Kang Qin,Li Lin,Ciyong Lu,Weiqing Chen,Vivian Yawei Guo
出处
期刊:Aging Clinical and Experimental Research [Springer Science+Business Media]
卷期号:34 (4): 767-774 被引量:8
标识
DOI:10.1007/s40520-021-02003-w
摘要

Aging is accompanied by chronic low-grade inflammation (inflammaging), which is a risk factor for low handgrip strength (HGS) and activities of daily living (ADL) disability.To explore the association between C-reactive protein (CRP) and ADL disability in Chinese elderly individuals and to further evaluate the mediating role of HGS in this association.We used data from the China Health and Retirement Longitudinal Study (CHARLS) that were collected in 2015. A total of 3601 elderly individuals aged ≥ 60 years were included. Baron and Kenny's causal steps method was used to explore the possible mediating role of HGS in the associations between CRP and ADL disability. Karlson-Holm-Breen method was further applied to decompose total effect into direct effect and indirect effect via HGS. Subgroup analysis was conducted by sex and age.A high level of CRP (≥ 3 mg/L) was significantly associated with ADL disability after adjustment for covariates (OR = 1.50, 95% CI = 1.17-1.94). After introducing HGS into the model, the risk estimate was reduced but still significant (OR = 1.40, 95% CI = 1.08-1.81). The proportional mediation through HGS was 14.71%. Similar results were observed in both sexes and in participants aged < 70 years.CRP was positively associated with the risk of ADL disability in Chinese elderly individuals, and this association was mediated by HGS. Improving muscle strength in combination with anti-inflammatory treatment may have a beneficial effect to maintain ADL ability. Further randomized controlled trials on this topic are necessary.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
C2750完成签到,获得积分10
刚刚
haiwei完成签到 ,获得积分10
1秒前
开放素完成签到 ,获得积分10
4秒前
西宁完成签到,获得积分10
5秒前
Cai完成签到,获得积分10
5秒前
傻傻的磬完成签到 ,获得积分10
5秒前
紫麒麟完成签到,获得积分10
7秒前
热情的花瓣完成签到 ,获得积分10
8秒前
乔一乔完成签到,获得积分10
11秒前
浅浅完成签到,获得积分10
12秒前
平淡尔琴完成签到,获得积分10
13秒前
我很好完成签到 ,获得积分10
15秒前
小白鞋完成签到 ,获得积分10
18秒前
帅气的藏鸟完成签到,获得积分10
19秒前
摘星012完成签到 ,获得积分10
19秒前
demian完成签到,获得积分20
20秒前
woshiwuziq完成签到 ,获得积分10
22秒前
drtianyunhong完成签到,获得积分10
22秒前
八八九九九1完成签到,获得积分10
26秒前
优雅的千雁完成签到,获得积分10
27秒前
没用的三轮完成签到,获得积分10
28秒前
30秒前
你我的共同完成签到 ,获得积分10
32秒前
mayberichard完成签到,获得积分10
34秒前
风信子deon01完成签到,获得积分10
37秒前
Pt-SACs发布了新的文献求助10
37秒前
香山叶正红完成签到 ,获得积分10
38秒前
wsg完成签到,获得积分10
38秒前
serendipity完成签到 ,获得积分10
40秒前
爆米花应助Yong-AI-BUPT采纳,获得10
41秒前
Pt-SACs完成签到,获得积分10
46秒前
刚子完成签到 ,获得积分10
47秒前
nicky完成签到 ,获得积分10
47秒前
果冻橙完成签到,获得积分10
49秒前
49秒前
田様应助科研通管家采纳,获得10
49秒前
Xiaoxiao应助科研通管家采纳,获得10
49秒前
思源应助科研通管家采纳,获得10
49秒前
50秒前
52秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513391
关于积分的说明 11167428
捐赠科研通 3248822
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875116
科研通“疑难数据库(出版商)”最低求助积分说明 804664