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Transcranial Alternating Current Stimulation at Alpha Frequency Reduces Pain When the Intensity of Pain is Uncertain

刺激(心理学) 经颅交流电刺激 体感系统 刺激 阿尔法(金融) 医学 强度(物理) 麻醉 听力学 心理学 神经科学 磁刺激 发展心理学 认知心理学 心理测量学 量子力学 结构效度 物理
作者
Laura J. Arendsen,Siobhan Hugh‐Jones,Donna M. Lloyd
出处
期刊:The Journal of Pain [Elsevier BV]
卷期号:19 (7): 807-818 被引量:45
标识
DOI:10.1016/j.jpain.2018.02.014
摘要

Alpha activity directly before pain onset has been implicated in pain experience with higher prestimulus alpha associated with lower reported pain. However, expectations about pain intensity also seem to affect prestimulus alpha activity. To date, evidence for a relationship between alpha activity and pain experience has been largely correlational. Transcranial alternating current stimulation at alpha frequency (alpha tACS) permits direct manipulation of alpha activity and therefore an examination of the potential causal relationship between alpha activity and pain. We investigated whether somatosensory alpha tACS could reduce pain experience and whether this was influenced by uncertainty about pain intensity. In a within-subjects design, perceived pain intensity and unpleasantness were assessed in 23 participants during alpha tACS and sham stimulation. Visual cues preceding the pain stimulus were used to manipulate uncertainty. A significant tACS × Uncertainty × Stimulus intensity interaction was found for reported pain intensity (F2,44 = 4.50, P = .017, partial η2 = .17) and unpleasantness (F1,22 = 4.78, P = .040, partial η2 = .18). Pain experience during the application of somatosensory alpha tACS was significantly lowered compared with sham stimulation, but only when the intensity of an upcoming stimulus was uncertain.To our knowledge, this is the first study to suggest that somatosensory alpha tACS might lead to a reduction in pain. Interventions targeting alpha activity may have the potential to alleviate chronic pain. However, a patient's expectation about the intensity of upcoming pain must also be taken into account.
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