矿化(土壤科学)
槲皮素
医学
内科学
内分泌学
化学
生物化学
抗氧化剂
有机化学
氮气
作者
Jubran K. Hassan,Adheed Khalid Sharrad,Falah Hassan Sheri
出处
期刊:Advances in pharmacology and pharmacy
[Horizon Research Publishing Co., Ltd.]
日期:2018-04-01
卷期号:6 (2): 43-49
被引量:12
标识
DOI:10.13189/app.2018.060202
摘要
Background: Diabetes associated with multiple metabolic problems in the body, including bone mineralization remodeling, osteoporosis and increase risk of fracture.Quercetin is natural flavonoids and according to animal studies; it has potent antioxidant, antidiabetic and protective effect against bone loss due to various causes.Objectives: explore effect of quercetin as nutritional supplement administrated orally on some bone mineralization bio-markers such as calcium, vitamin D and osteocalcin in Iraqi diabetic patients.Methods: interventional double-blind placebo randomized controlled study in which 40 patients with type 2 diabetes mellitus (age range 40-45) assigned randomly (using simple randomization) in either control (n=20) or study (n=20) group.Study group received Quercetin oral supplement as 500mg capsule once daily for three months.Venous blood was used for measuring Serum calcium, 25(OH) vitamin D and osteocalcin at base line and after 3 months.Results: After 3 months treatment with Quercetin; levels of Osteocalcin (28.1±7.6), serum calcium (9.2±1.8) and 25(OH) vitamin D (26.6±8.7) were significantly (p<0.05)higher than pretreatment values of osteocalcin (24.0±8.6);serum calcium (7.0±2.2) and 25(OH) vitamin D (20.6±7.7) and control values of serum calcium (6.8±2.0) and 25(OH) vitamin D (20.8±7.4), but not Osteocalcin (25.2±9.0).There was also significant correlation between use of quercetin; elevation of serum calcium and osteocalcin (r= 0.454; p= 0.032), indicating modulation in bone mineralization.Conclusions: Quercetin's use in diabetic patients may elevate Serum level of Calcium; 25(OH) vitamin D and may modulate bone mineralization represented by elevation of osteocalcin.
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