Allometric scaling of skin thickness, elasticity, viscoelasticity to mass for micro-medical device translation: from mice, rats, rabbits, pigs to humans

异速滴定 刚度 粘弹性 生物医学工程 弹性(物理) 缩放比例 猪皮 材料科学 弹性模量 计算机科学 复合材料 生物 医学 数学 生态学 几何学
作者
Jonathan Wei,Grant Edwards,Darren J. Martin,Han Huang,Michael L. Crichton,M. A. F. Kendall
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:7 (1) 被引量:166
标识
DOI:10.1038/s41598-017-15830-7
摘要

Abstract Emerging micro-scale medical devices are showing promise, whether in delivering drugs or extracting diagnostic biomarkers from skin. In progressing these devices through animal models towards clinical products, understanding the mechanical properties and skin tissue structure with which they interact will be important. Here, through measurement and analytical modelling, we advanced knowledge of these properties for commonly used laboratory animals and humans (~30 g to ~150 kg). We hypothesised that skin’s stiffness is a function of the thickness of its layers through allometric scaling, which could be estimated from knowing a species’ body mass. Results suggest that skin layer thicknesses are proportional to body mass with similar composition ratios, inter- and intra-species. Experimental trends showed elastic moduli increased with body mass, except for human skin. To interpret the relationship between species, we developed a simple analytical model for the bulk elastic moduli of skin, which correlated well with experimental data. Our model suggest that layer thicknesses may be a key driver of structural stiffness, as the skin layer constituents are physically and therefore mechanically similar between species. Our findings help advance the knowledge of mammalian skin mechanical properties, providing a route towards streamlined micro-device research and development onto clinical use.
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