Successful Bacteriophage Therapy for Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection in a Cystic Fibrosis Patient

医学 铜绿假单胞菌 粘菌素 肺炎 囊性纤维化 呼吸衰竭 假单胞菌感染 移植 恶化 内科学 血液透析 肾脏替代疗法 不利影响 肾移植 重症监护医学 抗生素 微生物学 细菌 遗传学 生物
作者
Nancy Law,Cathy Logan,C. Furr,Susan M. Lehman,Sandra Morales,F. Rosas,A. Gaidamaka,Igor P Bilinsky,P. Grint,Robert T. Schooley,Saima Aslam
出处
期刊:Journal of Heart and Lung Transplantation [Elsevier]
卷期号:38 (4): S38-S38 被引量:4
标识
DOI:10.1016/j.healun.2019.01.078
摘要

Introduction Bacteriophages are host-specific lytic viruses that are of increasing interest as adjunctive therapy for treatment of multi-drug resistant (MDR) pathogens. Case Report We describe the use of bacteriophage therapy (BT) in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation who was admitted for respiratory failure requiring mechanical ventilation for 12 days. The hospital course was complicated by MDR Pseudomonas aeruginosa (PA) pneumonia, persistent respiratory failure, and colistin-induced renal failure (listed for concomitant kidney transplant). Due to worsening clinical status, BT was explored as an adjunct to antibiotics. The patient was approved under emergency IND#17710 by the FDA to receive AB-PA01 (combination of 4 lytic phages) active against the clinical PA isolates. This was given every 6 hours intravenously (IV) for 8 weeks. As noted in Figure 1, the patient was bed-bound due to severe dyspnea and required 30 L/min O2 via high flow nasal cannula (NC) at BT initiation. MDR PA pneumonia resolved by Day 7. Her respiratory status continued to improve and by end of therapy (EOT) she was on 4 L/min O2 via NC and was able to work with physical therapy. No adverse events related to BT occurred. There was no recurrent pneumonia or CF exacerbation within 90-days following the end of treatment. Renal failure resolved once off colistin and the patient was removed from the kidney transplant waitlist. Summary We describe the successful use of BT in a CF patient awaiting lung transplant. Given the concern for MDR PA in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
yapo发布了新的文献求助10
刚刚
罗帕霉素完成签到,获得积分10
1秒前
Jasper应助hugo采纳,获得10
1秒前
善学以致用应助云桑采纳,获得10
1秒前
公爵完成签到,获得积分10
2秒前
一颗柚子完成签到,获得积分10
2秒前
FashionBoy应助傣妹纸如裴洱采纳,获得10
2秒前
yxli完成签到,获得积分10
3秒前
3秒前
4秒前
LBJ23发布了新的文献求助10
4秒前
psycho发布了新的文献求助10
5秒前
5秒前
screct关注了科研通微信公众号
6秒前
6秒前
云生甲地完成签到,获得积分10
6秒前
Moss发布了新的文献求助10
7秒前
8秒前
今后应助kyf采纳,获得10
8秒前
万能图书馆应助枯木逢春采纳,获得10
8秒前
龙龙完成签到,获得积分10
8秒前
8秒前
你报完成签到,获得积分10
8秒前
不配.应助愉快幻悲采纳,获得10
9秒前
贺知什么书完成签到,获得积分10
9秒前
善学以致用应助psycho采纳,获得10
10秒前
10秒前
ggjhgh发布了新的文献求助30
10秒前
李白白白发布了新的文献求助10
10秒前
Ava应助Fu采纳,获得10
11秒前
你报发布了新的文献求助10
11秒前
壮观的元冬完成签到,获得积分10
11秒前
公爵发布了新的文献求助30
12秒前
Accepted应助王宇杰采纳,获得10
12秒前
Vin完成签到 ,获得积分10
12秒前
搜集达人应助hhc采纳,获得10
13秒前
追寻锦程完成签到,获得积分10
14秒前
大意的饼干完成签到,获得积分10
15秒前
hugo发布了新的文献求助10
15秒前
板凳发布了新的文献求助40
15秒前
高分求助中
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
Дружба 友好报 (1957-1958) 1000
The Data Economy: Tools and Applications 1000
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 700
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufe 700
A Dissection Guide & Atlas to the Rabbit 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3101379
求助须知:如何正确求助?哪些是违规求助? 2752746
关于积分的说明 7620795
捐赠科研通 2405017
什么是DOI,文献DOI怎么找? 1276094
科研通“疑难数据库(出版商)”最低求助积分说明 616692
版权声明 599058