光热治疗
癌细胞
细胞
细胞膜
体内
靶向给药
免疫系统
材料科学
癌症
纳米颗粒
间充质干细胞
癌症研究
膜
药物输送
纳米技术
纳米医学
癌症治疗
化学
生物物理学
肿瘤微环境
纳米载体
光热效应
细胞生物学
医学
生物
免疫学
生物化学
生物技术
内科学
作者
Mengyin Wu,Wenjun Le,Tianxiao Mei,Yuchong Wang,Bingdi Chen,Zhongmin Liu,Chunyu Xue
摘要
Targeted drug delivery by nanoparticles (NPs) is an essential technique to achieve the ideal therapeutic effect for cancer. However, it requires large amounts of work to imitate the biomarkers on the surface of the cell membrane and cannot fully retain the bio-function and interactions among cells. Cell membranes have been studied to form biomimetic NPs to achieve functions like immune escape, targeted drug delivery, and immune modulation, which inherit the ability to interact with the in vivo environments. Currently, erythrocyte, leukocyte, mesenchymal stem cell, cancer cell and platelet have been applied in coating photothermal agents and anti-cancer drugs to achieve increased photothermal conversion efficiency and decreased side effects in cancer ablation. In this review, we discuss the recent development of cell membrane-coated NPs in the application of photothermal therapy and cancer targeting. The underlying biomarkers of cell membrane-coated nanoparticles (CMNPs) are discussed, and future research directions are suggested.
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