9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics

威利斯圆 磁共振成像 大脑前动脉 脑动脉 医学 脑循环 解剖 颈内动脉 前交通动脉 动脉瘤 血流 颈总动脉 生物医学工程 颈动脉 内科学 放射科 心脏病学 缺血 大脑中动脉
作者
Vincent M. Tutino,Hamidreza Rajabzadeh-Oghaz,Anusha Ramesh Chandra,Liza Gutierrez,Ferdinand Schweser,Marilena Preda,Aichi Chien,Kunal Vakharia,Ciprian N. Ionita,Adnan H. Siddiqui,John Kolega
出处
期刊:Current Neurovascular Research [Bentham Science Publishers]
卷期号:15 (4): 312-325 被引量:7
标识
DOI:10.2174/1567202616666181127165943
摘要

Background: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW). Method: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left Common Carotid Artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries. One additional mouse was used as a wild-type control. Magnetic Resonance Imaging (MRI) at 9.4 Tesla (T) was used to serially image the mouse CoW over three months, and to obtain threedimensional images for use in Computational Fluid Dynamic (CFD) simulations. Terminal vascular corrosion casting and scanning electron microscope imaging were used to identify regions of macroscopic and microscopic arterial damage. Results: We demonstrated the feasibility of detecting and serially measuring pathologic cerebral vascular changes in the mouse CoW, specifically in the anterior vasculature. These changes were characterized by bulging and increased vessel tortuosity on the anterior cerebral artery and aneurysm- like remodeling at the right olfactory artery origin. The resolution of the 9.4T system further allowed us to perform CFD simulations in the anterior CoW, which showed a correlation between elevated wall shear stress and pathological vascular changes. Conclusion: In the future, serial high-resolution MRI could be useful for characterizing the flow environments corresponding to other pathologic remodeling processes in the mouse CoW, such as aneurysm formation, subarachnoid hemorrhage, and ischemia. Keywords: Animal model, carotid artery ligation, hemodynamics, computational fluid dynamics, magnetic resonance imaging, vascular corrosion casting.
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