亚稳态
体积分数
乙腈
化学
甲醇
拉曼光谱
多态性(计算机科学)
摩尔分数
相(物质)
过饱和度
结晶
分数(化学)
丙酮
转化(遗传学)
结晶学
材料科学
色谱法
物理化学
有机化学
基因型
物理
光学
基因
生物化学
作者
Lek Wantha,Neeranuch Punmalee,Adrian E. Flood
标识
DOI:10.1002/ceat.201800699
摘要
Abstract Solution‐mediated polymorphic transformation (SMPT) of the metastable polymorph B of L ‐histidine ( L ‐his) into the stable polymorph A in water‐antisolvent solutions was performed. Methanol, acetone, and acetonitrile served as antisolvents. The SMPT was studied via nucleated batch antisolvent crystallization process by determining the change of the fraction of the stable polymorph A of L ‐his in the crystal phase with time during the crystallization process. The fraction of the stable polymorph A of L ‐his was assessed offline by Raman spectroscopy. The transformation time depended on the fractions of form A obtained at the initial stage of crystallization. The transformation rate of the metastable polymorph B into the stable polymorph A at lower antisolvent volume fraction was faster than at higher antisolvent volume fraction. The transformation time of polymorph B into polymorph A in water‐acetonitrile solution was the shortest compared to the other solutions.
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