医学
非酒精性脂肪肝
脂肪肝
内科学
等位基因
胰岛素抵抗
胃肠病学
基因型
内分泌学
生物信息学
疾病
肥胖
遗传学
生物
基因
作者
Jinzhi Wang,Hongyan Cao,Jian-Neng Chen,Qin Pan
出处
期刊:World Journal of Clinical Cases
[Baishideng Publishing Group Co (World Journal of Clinical Cases)]
日期:2018-08-16
卷期号:6 (8): 167-175
被引量:24
标识
DOI:10.12998/wjcc.v6.i8.167
摘要
Non-alcoholic fatty liver disease (NAFLD) has now become the leading cause of chronic liver disease with its growing incidence worldwide.Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C > G reflects one of the critical genetic factors that confers high-risk to NAFLD.However, the role of PNPLA3 polymorphism in NAFLD treatment remains uncertain.Here, the present review reveals that NAFLD patients with G-allele at PNPLA3 rs738409 (PNPLA3 148M variant) are sensitive to therapies of lifestyle modification, dipeptidyl peptidase-4 inhibitors, and bariatric surgery.They exhibit much significant reduction of liver fat content, in concurrence with weigh loss and abolished insulin resistance, as compared to those of C-allele carriers.In contrast, patients bearing PNPLA3 rs738409 C-allele (PNPLA3 148I variant), instead of G-allele, demonstrate greater beneficial effects by omega-3 poly-unsaturated fatty acids and statin intervention.Improved adipose tissue-liver interaction and decrease in intrahepatic triglyceride efflux may contribute to the PNPLA3 rs738409 related diversities in therapeutic efficacy.Therefore, PNPLA3 rs738409 underlies the response to a variety of treatments, which warrants a personalized, precise medicine in NAFLD on the basis of genotype stratification.
科研通智能强力驱动
Strongly Powered by AbleSci AI