乳状液
防腐剂
化学
抗菌剂
金黄色葡萄球菌
白色念珠菌
色谱法
黄曲霉
防腐剂
微生物学
食品科学
有机化学
细菌
生物
遗传学
作者
Julia Puschmann,Michael E. Herbig,Christel C. Müller‐Goymann
标识
DOI:10.1016/j.ejpb.2018.08.007
摘要
Antimicrobial testing is a time consuming and cost-intensive but essential method for evaluation of newly developed pharmaceutical formulations for topical use. In this study the correlation between free preservative concentration in emulsion gels measured by equilibrium dialysis and the successful preservative effectiveness testing for Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Aspergillus brasiliensis (analyzed according to Ph. Eur. and USP) was investigated. The higher the lipophilicity of the oil phase and the lower the content of the aqueous phase with regard to dissolved ingredients the more preferably distributed is phenoxyethanol to the water phase and, consequently, the higher was the efficacy against the microbes. Increased emulsifier concentrations reduced the free amount of the preservative due to micellar interactions. Aspergillus brasiliensis was the most resistant and Staphylococcus aureus the most sensitive germ towards phenoxyethanol in o/w-emulsion gels.
科研通智能强力驱动
Strongly Powered by AbleSci AI