How Can Xenosensors Act in Chemical Detoxification Metabolism?

There are some disparities between pharmacological and toxicological xenobiotic receptor (xenosensors) pathways. These variations include receptor models that indicate several toxic patterns. Such models have demanded some update from traditional medical receptor relations studied by pharmacologists. These may include the response time, the molecular level, and unclear directions of toxicological metabolism. Xenosensors activities were affected by many factors that include genetic elements, physiological status, xenobiotic complication, and species-specific variations. Thus, this review aims to highlight the most advanced features of xenosensors related to toxicant biotransformations and other patterns such as characteristics, recognition, and the relations between different xenosensors. Keywords: AhR, nuclear receptors, species variations, toxic metabolism, Xenosensors, detoxification.