Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder

楔前 舌回 边缘叶 额上回 中央后回 额中回 颞中回 库尼乌斯 顶叶上小叶 颞下回 睡眠(系统调用) 额内侧回 基于体素的形态计量学 快速眼动睡眠行为障碍 顶叶 医学 颞上回 中央前回 梭状回 神经科学 多导睡眠图 颞叶 心理学 快速眼动睡眠 眼球运动 非快速眼动睡眠 萎缩 灰色(单位) 磁共振成像 功能磁共振成像 放射科 癫痫
作者
Xin Han,Xiu-Ming Li,Weijun Tang,Hui Yu,Ping Wu,Jingjie Ge,Jian Wang,Chuantao Zuo,Kuangyu Shi
出处
期刊:Neural Regeneration Research [Medknow]
卷期号:14 (5): 868-868 被引量:12
标识
DOI:10.4103/1673-5374.249235
摘要

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6 ± 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7 ± 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Ethics Committee of Huashan Hospital (approval No. KY2013-336) on January 6, 2014. This trial was registered in the ISRCTN registry (ISRCTN18238599).
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