骨免疫学
骨重建
骨吸收
免疫系统
细胞生物学
破骨细胞
平衡
骨细胞
化学
基质骨
免疫学
骨组织
神经科学
生物
内分泌学
解剖
生物化学
兰克尔
受体
软骨
激活剂(遗传学)
作者
Jaerang Rho,Takami Miki,Yongwon Choi
出处
期刊:Molecules and Cells
[Korean Society for Molecular and Cellular Biology]
日期:2004-02-01
卷期号:17 (1): 1-9
被引量:43
标识
DOI:10.1016/s1016-8478(23)12997-9
摘要
Bone is a dynamic tissue that provides mechanical support, physical protection, and enables movement. Bone also serves as a storage site for minerals and is where blood cells are produced. Bone homeostasis is regulated by the balance between bone formation and resorption, and involves the coordinated action of osteoblasts and osteoclasts. Osteoblasts are bone-forming cells that secrete organic matrix molecules, while osteoclasts are derived from hematopoietic precursors and resorb bone matrix. Although osteoblasts and osteoclasts are the major regulators of bone metabolism and are regulated by the local microenvironment, it has recently come to be appreciated that skeletal system homeostasis is greatly influenced by components of the immune system. For example, some pathological bone resorption observed under inflammatory conditions has been shown to be due, in part, to direct and indirect effects of activated T cells on osteoclasts. In this regard, we would like to review current progress and perspectives in "osteoimmunology", an interdisciplinary research principle governing the cross-talk between the bone and immune systems. Better understanding of how the osteoimmune system operates in normal and pathological situations is likely to lay the groundwork for future therapies for the variety of diseases that affect both bone and the immune system.
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