牙槽
PLGA公司
生物医学工程
生物相容性
小猎犬
生长因子
材料科学
水泥
化学
磷酸钙骨水泥
血小板源性生长因子受体
骨愈合
牙科
复合材料
纳米技术
解剖
冶金
医学
纳米颗粒
内科学
生物化学
受体
作者
Rosa P. Félix Lanao,J.A. Hoekstra,Joop G.C. Wolke,Sander C.G. Leeuwenburgh,Adelina S. Plachokova,Otto C. Boerman,Jeroen J.J.P. van den Beucken,John A. Jansen
摘要
The present study aimed to provide information on material degradation and subsequent alveolar bone formation, using composites consisting of calcium phosphate cement (CPC) and poly(lactic-co-glycolic) acid (PLGA) with different microsphere morphology (hollow vs dense). In addition to the plain CPC–PLGA composites, loading the microspheres with the growth factors platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF) was investigated. A total of four different CPC composites were applied into one-wall mandible bone defects in beagle dogs in order to evaluate them as candidates for alveolar bone regeneration. These composites consisted of CPC and hollow or dense PLGA microspheres, with or without the addition of PDGF–IGF growth factor combination (CPC–hPLGA, CPC–dPLGA, CPC–hPLGAGF, CPC–dPLGAGF). Histological evaluation revealed significantly more bone formation in CPC–dPLGA than in CPC–hPLGA composites. The combination PDGF–IGF enhanced bone formation in CPC–hPLGA materials, but significantly more bone formation occurred when CPC–dPLGA was used, with or without the addition of growth factors. The findings demonstrated that CPC–dPLGA composite was the biologically superior material for use as an off-the-shelf material, due to its good biocompatibility, enhanced degradability and superior bone formation. Copyright © 2012 John Wiley & Sons, Ltd.
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