化学
烯烃复分解
吡咯烷
催化作用
产量(工程)
路易斯酸
烯烃纤维
复分解
有机化学
组合化学
聚合
冶金
材料科学
聚合物
作者
Fabian Huck,Lorenzo Catti,Gian Lino Reber,Konrad Tiefenbacher
标识
DOI:10.1021/acs.joc.1c02447
摘要
Chiral pyrrolidine derivatives are important building blocks for natural product synthesis. Carbonyl olefin metathesis has recently emerged as a powerful tool for the construction of such building blocks from chiral amino acid derivatives. Here, we demonstrate that the supramolecular resorcinarene catalyst enables access to chiral 2,5-dihydropyrroles under Brønsted acid catalysis. Moreover, this catalytic system even tolerated Lewis-basic-protecting groups like mesylates that are not compatible with alternative catalysts. As expected for conversion inside a closed cavity, the product yield and selectivity depended on the size of the substrates.
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