药物输送
药品
生物医学工程
壳聚糖
材料科学
流变仪
泊洛沙姆
化学
药理学
纳米技术
医学
共聚物
有机化学
复合材料
聚合物
流变学
作者
Yang Yu,Da Hae Kim,Eun Yeong Suh,Seong-Hun Jeong,Hyuk Chan Kwon,Thi Phuc Le,Yugyeong Kim,Sun-Ae Shin,Yong‐Ho Park,Kang Moo Huh
标识
DOI:10.1016/j.carbpol.2021.118969
摘要
We prepared a new injectable thermogel to enhance the efficiency of inner ear delivery of dexamethasone (DEX). Hexanoyl glycol chitosan (HGC) was synthesized and evaluated as an amphiphilic thermogel (Tgel ~ 32 °C) for use as a solubilizing agent as well as an injectable carrier for intratympanic delivery of the hydrophilic and hydrophobic forms of DEX. Various thermogel formulations with different drug types and concentrations were prepared, and their physicochemical and thermogelling properties were characterized by 1H NMR, ATR-FTIR, and rheometer. They exhibited versatile release kinetics from several hours to more than 2 weeks, depending on drug type and concentration. Our formulations further showed good residual stability for more than 21 days without any cytotoxicity or inflammation in the middle and inner ear and could deliver a considerably high drug concentration into the inner ear. Therefore, HGC thermogel has great potential as an effective and safe formulation for inner ear drug delivery.
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