LNA043 A NOVEL CANDIDATE FOR OSTEOARTHRITIS TREATMENT INDUCES CARTILAGE REGENERATION AND REVERSES THE OSTEOARTHRITIS TRANSCRIPTOME

Purpose: The goal of this study was to identify a disease modifying osteoarthritis drug (DMOAD) that regenerates healthy hyaline cartilage in osteoarthritis (OA) through differentiation of endogenous mesenchymal stem cells (MSCs) into chondrocytes and the production of healthy hyaline cartilage matrix. Using a phenotypic screen, we discovered LNA043, a derivative of the angiopoietin-like 3 (ANGPTL3) protein and confirmed that it promotes chondrogenesis in vitro and cartilage regeneration in vivo.