计算机科学
领域(数学)
清晰
分类
药物发现
光学(聚焦)
化学
人工智能
数学
物理
生物化学
纯数学
光学
作者
Justin Jurczyk,Jisoo Woo,Sojung F. Kim,Balu D. Dherange,Richmond Sarpong,Mark D. Levin
出处
期刊:Nature Synthesis
[Springer Nature]
日期:2022-04-11
卷期号:1 (5): 352-364
被引量:188
标识
DOI:10.1038/s44160-022-00052-1
摘要
Medicinal chemistry continues to be impacted by new synthetic methods. Particularly sought after, especially at the drug discovery stage, is the ability to enact the desired chemical transformations in a concise and chemospecific fashion. To this end, the field of organic synthesis has become captivated by the idea of 'molecular editing'-to rapidly build onto, change or prune molecules one atom at a time using transformations that are mild and selective enough to be employed at the late stages of a synthetic sequence. In this Review, the definition and categorization of a particularly promising subclass of molecular editing reactions, termed 'single-atom skeletal editing', are proposed. Although skeletal editing applies to both cyclic and acyclic compounds, this Review focuses on heterocycles, both for their centrality in medicinal chemistry and for the definitional clarity afforded by a focus on ring systems. A classification system is presented by highlighting methods (both historically important examples and recent advances) that achieve such transformations, with the goal to spark interest and inspire further development in this growing field.
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