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Neuroimaging gradient alterations and epileptogenic prediction in focal cortical dysplasia IIIa

立体脑电图 神经影像学 皮质发育不良 癫痫外科 颞叶 癫痫 海马硬化 医学 神经科学 放射科 心理学
作者
Jiajie Mo,Jianguo Zhang,Wenhan Hu,Xiaoqiu Shao,Lin Sang,Zhong Zheng,Chao Zhang,Yao Wang,Xiu Wang,Chang Liu,Baotian Zhao,Kai Zhang
出处
期刊:Journal of Neural Engineering [IOP Publishing]
卷期号:19 (2): 025001-025001 被引量:8
标识
DOI:10.1088/1741-2552/ac6628
摘要

Objective.Focal cortical dysplasia type IIIa (FCD IIIa) is a highly prevalent temporal lobe epilepsy but the seizure outcomes are not satisfactory after epilepsy surgery. Hence, quantitative neuroimaging, epileptogenic alterations, as well as their values in guiding surgery are worth exploring.Approach.We examined 69 patients with pathologically verified FCD IIIa using multimodal neuroimaging and stereoelectroencephalography (SEEG). Among them, 18 received postoperative imaging which showed the extent of surgical resection and 9 underwent SEEG implantation. We also explored neuroimaging gradient alterations along with the distance to the temporal pole. Subsequently, the machine learning regression model was employed to predict whole-brain epileptogenicity. Lastly, the correlation between neuroimaging or epileptogenicity and surgical cavities was assessed.Main results.FCD IIIa displayed neuroimaging gradient alterations on the temporal neocortex, morphology-signal intensity decoupling, low similarity of intra-morphological features and high similarity of intra-signal intensity features. The support vector regression model was successfully applied at the whole-brain level to calculate the continuous epileptogenic value at each vertex (mean-squared error = 13.8 ± 9.8).Significance.Our study investigated the neuroimaging gradient alterations and epileptogenicity of FCD IIIa, along with their potential values in guiding suitable resection range and in predicting postoperative seizure outcomes. The conclusions from this study may facilitate an accurate presurgical examination of FCD IIIa. However, further investigation including a larger cohort is necessary to confirm the results.
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