FGF21型
酒
饮酒量
消费(社会学)
人口
基底外侧杏仁核
激素
生物
医学
神经科学
扁桃形结构
内分泌学
成纤维细胞生长因子
内科学
环境卫生
受体
生物化学
社会科学
社会学
作者
Kyle H. Flippo,Samuel A.J. Trammell,Matthew P. Gillum,İltan Aklan,Misty B. Perez,Yavuz Yavuz,Nicholas K. Smith,Sharon O. Jensen-Cody,Bolu Zhou,Kristin E. Claflin,Amy Beierschmitt,Anders Fink‐Jensen,Filip K. Knop,Roberta M. Palmour,Brad A. Grueter,Deniz Atasoy,Matthew J. Potthoff
出处
期刊:Cell Metabolism
[Elsevier]
日期:2022-02-01
卷期号:34 (2): 317-328.e6
被引量:43
标识
DOI:10.1016/j.cmet.2021.12.024
摘要
Excessive alcohol consumption is a major health and social issue in our society. Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) suppresses alcohol consumption through actions in the brain in rodents, and genome-wide association studies have identified single nucleotide polymorphisms in genes involved with FGF21 signaling as being associated with increased alcohol consumption in humans. However, the neural circuit(s) through which FGF21 signals to suppress alcohol consumption are unknown, as are its effects on alcohol consumption in higher organisms. Here, we demonstrate that administration of an FGF21 analog to alcohol-preferring non-human primates reduces alcohol intake by 50%. Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala. Our results illustrate how FGF21 suppresses alcohol consumption through a specific population of neurons in the brain and demonstrate its therapeutic potential in non-human primate models of excessive alcohol consumption.
科研通智能强力驱动
Strongly Powered by AbleSci AI