清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Selenium protects against the likelihood of fetal neural tube defects partly via the arginine metabolic pathway

后代 医学 优势比 鸟氨酸 内科学 神经管 置信区间 四分位间距 内分泌学 精氨酸 怀孕 生物 生物化学 氨基酸 遗传学 胚胎
作者
Tian Tian,Jinming Liu,Xinchen Lu,Xinghua Qiu,Jing Wei,Chengrong Wang,Mengyuan Liu,Shengju Yin,Lei Jin,Linlin Wang,Zhiwen Li,Tong Zhu,Aiguo Ren
出处
期刊:Clinical Nutrition [Elsevier BV]
卷期号:41 (4): 838-846 被引量:4
标识
DOI:10.1016/j.clnu.2022.02.006
摘要

Neural tube defects (NTDs) are severe congenital malformations and have a complex etiology. This study aimed to explore the association between selected essential trace elements (ETEs) and metabolic pathway markers in the serum of women and the likelihood of NTDs.The study included 99 mothers of offspring with and 114 mothers of offspring without NTDs. Five ETEs (iron, zinc, selenium [Se], cobalt, and molybdenum) and 106 metabolic pathway markers in maternal serum were quantified. The associations between ETEs and metabolic pathway markers and the chance of NTDs were examined. Mediating effects of the metabolic pathway markers on the association between Se and the likelihood of NTDs were evaluated.Compared to a Se concentration below the median, a concentration above the median was associated with a decreased chance of NTDs with an odds ratio of 0.29 (95% confidence interval: 0.11-0.66). The concentrations of 32 metabolic pathway markers differed between mothers of offspring with and without NTDs; five of these (asymmetric dimethylarginine, ornithine, glutamate, proline, and phenylalanine) were associated with increased chances of NTDs, with adjusted odds ratios of 3.01 (1.31-7.31), 2.79 (1.18-6.86), 2.38 (1.03-5.75), 2.41 (1.05-5.75), and 2.27 (1.09-5.40), respectively, for the higher interquartile of concentration compared to the lower one. Three arginine pathway metabolic markers (i.e., dimethylarginine, ornithine, and proline) mediated the association between Se and the occurrence of NTDs.This study suggests an association between Se and a reduced chance of NTDs. The arginine pathway may play a role in mediating this association.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
沐浠完成签到 ,获得积分10
4秒前
葛力完成签到,获得积分20
8秒前
科研通AI2S应助葛力采纳,获得10
20秒前
21秒前
宇文非笑完成签到 ,获得积分0
29秒前
科研通AI5应助laodai8855采纳,获得20
30秒前
32秒前
乾坤侠客LW完成签到,获得积分10
1分钟前
1分钟前
lixuebin完成签到 ,获得积分10
1分钟前
科研通AI2S应助葛力采纳,获得10
1分钟前
lxh完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
laodai8855发布了新的文献求助20
2分钟前
2分钟前
3分钟前
科研通AI5应助梨子茶采纳,获得30
3分钟前
3分钟前
bju发布了新的文献求助10
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
搜集达人应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
bju完成签到,获得积分10
3分钟前
4分钟前
梨子茶发布了新的文献求助30
4分钟前
mczhu完成签到,获得积分10
4分钟前
聪慧芷巧完成签到 ,获得积分10
4分钟前
qqJing完成签到,获得积分10
4分钟前
deallyxyz应助草木采纳,获得10
4分钟前
4分钟前
4分钟前
常有李完成签到,获得积分10
5分钟前
5分钟前
默默孱完成签到 ,获得积分10
5分钟前
JamesPei应助汎影采纳,获得10
5分钟前
5分钟前
Lucas应助汎影采纳,获得10
5分钟前
wwe完成签到,获得积分10
5分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513318
关于积分的说明 11167279
捐赠科研通 3248691
什么是DOI,文献DOI怎么找? 1794414
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804652