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Selenium protects against the likelihood of fetal neural tube defects partly via the arginine metabolic pathway

后代 医学 优势比 鸟氨酸 内科学 神经管 置信区间 四分位间距 内分泌学 精氨酸 怀孕 生物 生物化学 氨基酸 遗传学 胚胎
作者
Tian Tian,Jinming Liu,Xinchen Lu,Xinghua Qiu,Jing Wei,Chengrong Wang,Mengyuan Liu,Shengju Yin,Lei Jin,Linlin Wang,Zhiwen Li,Tong Zhu,Aiguo Ren
出处
期刊:Clinical Nutrition [Elsevier BV]
卷期号:41 (4): 838-846 被引量:4
标识
DOI:10.1016/j.clnu.2022.02.006
摘要

Neural tube defects (NTDs) are severe congenital malformations and have a complex etiology. This study aimed to explore the association between selected essential trace elements (ETEs) and metabolic pathway markers in the serum of women and the likelihood of NTDs.The study included 99 mothers of offspring with and 114 mothers of offspring without NTDs. Five ETEs (iron, zinc, selenium [Se], cobalt, and molybdenum) and 106 metabolic pathway markers in maternal serum were quantified. The associations between ETEs and metabolic pathway markers and the chance of NTDs were examined. Mediating effects of the metabolic pathway markers on the association between Se and the likelihood of NTDs were evaluated.Compared to a Se concentration below the median, a concentration above the median was associated with a decreased chance of NTDs with an odds ratio of 0.29 (95% confidence interval: 0.11-0.66). The concentrations of 32 metabolic pathway markers differed between mothers of offspring with and without NTDs; five of these (asymmetric dimethylarginine, ornithine, glutamate, proline, and phenylalanine) were associated with increased chances of NTDs, with adjusted odds ratios of 3.01 (1.31-7.31), 2.79 (1.18-6.86), 2.38 (1.03-5.75), 2.41 (1.05-5.75), and 2.27 (1.09-5.40), respectively, for the higher interquartile of concentration compared to the lower one. Three arginine pathway metabolic markers (i.e., dimethylarginine, ornithine, and proline) mediated the association between Se and the occurrence of NTDs.This study suggests an association between Se and a reduced chance of NTDs. The arginine pathway may play a role in mediating this association.
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