基因型
优势比
血管炎
荟萃分析
等位基因
内科学
医学
胃肠病学
血管紧张素转换酶
多态性(计算机科学)
川崎病
置信区间
免疫学
生物
遗传学
疾病
基因
动脉
血压
作者
Young Ho Lee,Sung Jae Choi,Jong Dae Ji,Gwan Gyu Song
标识
DOI:10.1177/1470320311434240
摘要
To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme (ACE) confers susceptibility to vasculitis.A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis.Twelve studies, including four on Behçet's disease (BD), four on Henoch-Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener's granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214-1.468, p = 7.4 × 10(-5)). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017-1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021-2.049, p = 0.038; OR 1.881, 95% CI 1.385-2.595, p = 6.6 × 10(-5)). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism.This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.
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