Rh(III)‐Catalyzed C6‐Selective C−H 3‐Oxoalkylation of 2‐Pyridones with Allylic Alcohols

Abstract Rhodium(III)‐catalyzed C6‐selective C−H 3‐oxoalkylation of 2‐pyridones was developed with commercially available allylic alcohols as the 3‐oxoalkyl sources. In this reaction, the excellent site selectivity was controlled by the 2‐pyridyl directing group on the nitrogen of the pyridone ring. This reaction features good functional group tolerance and the generation of 6‐(3‐oxoalkyl) pyridones in moderate to good yields.