Lipid Metabolism

ferase (CPTI) activity, thereby preventing fatty acid import into the mitochondrial matrix for β-oxidation.• Lipids can modify proteins to alter their function.Notable modifications are N-myristoylation, S-or N-palmitoylation, and S-prenylation.• Lipids, such as eicosanoids, phosphoinositides, and sphingolipids, serve as signaling molecules.• The cholesterol biosynthetic pathway initiates in the cytosol and is controlled by the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase), the target of statins (class of cholesterol-lowering drugs).