效应器
免疫系统
免疫学
肿瘤微环境
癌症
肿瘤进展
CD8型
癌症免疫疗法
生物
免疫疗法
癌症研究
医学
内科学
作者
Shannon M. Liudahl,Lisa M. Coussens
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2018-01-01
卷期号:: 97-116
被引量:7
标识
DOI:10.1016/b978-0-12-809819-6.00008-3
摘要
In addition to their functional relevance in pathogenic infection and autoimmune disease, leukocytes also play critical roles in regulating cancer progression, and immunotherapies designed to enhance antitumor immune responses are becoming mainstays in clinical oncology. Complex interactions between different leukocyte subtypes recruited to neoplastic microenvironments can result in either tumor promotional or tumor suppressive programming. Therefore, understanding the mechanisms regulating the balance between these states is critical for developing improved immune-based cancer therapeutics. Effector and memory CD8+ T cells are well established as key mediators of tumor cytotoxicity, but the roles of CD4+ T cells in tumor microenvironments have not been as extensively explored. In this chapter, we review current understandings of the diverse roles played by CD4+ T helper cell subsets in either promoting or suppressing progression of solid tumors.
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