生物
转录因子
计算生物学
染色质
遗传学
基因表达调控
人类基因组
Cis监管模块
基因组
增强子
基因
进化生物学
作者
Samuel A. Lambert,Arttu Jolma,Laura F. Campitelli,Pratyush Kumar Das,Yimeng Yin,Mihai Albu,Xiaoting Chen,Jussi Taipale,Timothy R. Hughes,Matthew T. Weirauch
出处
期刊:Cell
[Elsevier]
日期:2018-02-01
卷期号:172 (4): 650-665
被引量:2448
标识
DOI:10.1016/j.cell.2018.01.029
摘要
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and transcription, forming a complex system that guides expression of the genome. Despite keen interest in understanding how TFs control gene expression, it remains challenging to determine how the precise genomic binding sites of TFs are specified and how TF binding ultimately relates to regulation of transcription. This review considers how TFs are identified and functionally characterized, principally through the lens of a catalog of over 1,600 likely human TFs and binding motifs for two-thirds of them. Major classes of human TFs differ markedly in their evolutionary trajectories and expression patterns, underscoring distinct functions. TFs likewise underlie many different aspects of human physiology, disease, and variation, highlighting the importance of continued effort to understand TF-mediated gene regulation.
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