肿胀 的
自愈水凝胶
傅里叶变换红外光谱
扫描电子显微镜
化学
胃蛋白酶
葡聚糖
化学工程
色谱法
核化学
材料科学
生物化学
高分子化学
酶
复合材料
工程类
作者
Kai Zhu,Xiaohong Chen,Da Yu,Yue He,Guanglei Song
摘要
This study investigates a novel hydrogel synthesis method and its bio-release property. This hydrogel, with a three-dimensional network structure based on Auricularia polytricha β-glucan, was characterised by means of Fourier transform infrared spectroscopy, 1 H NMR and scanning electron microscopy. Vitamin B12 (VB12 , cobalamin) as a hydrophilic functional food component was entrapped into these hydrogels. The in vitro release profile of VB12 was established in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF).The results showed that the hydrogel had medium pore size from 30 to 300 µm, and the swelling ratio increased with the degree of substitution. The hydrogel demonstrated good stability in SGF and bio-release capability in SIF for VB12 . The accumulated release rate is about 80% in SIF and below 20% in SGF, which indicated the significant different release property in stomach and intestine.The Auricularia polytricha β-glucan-based hydrogel has a good swelling ratio, pepsin stability and pancrelipase-catalysed biodegradation property. The bio-release rate is significantly different in SIF and SGF, which indicated that this hydrogel could be a good intestinal target carrier of VB12 . © 2017 Society of Chemical Industry.
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