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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRecent Developments in Two-Dimensional Liquid Chromatography: Fundamental Improvements for Practical ApplicationsBob W. J. Pirok*Bob W. J. PirokUniversity of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical-Chemistry Group, Science Park 904, 1098 XH Amsterdam, The NetherlandsTI-COAST, Science Park 904, 1098 XH Amsterdam, The Netherlands*E-mail: [email protected]More by Bob W. J. PirokView Biographyhttp://orcid.org/0000-0002-4558-3778, Dwight R. StollDwight R. StollDepartment of Chemistry, Gustavus Adolphus College, Saint Peter, Minnesota 56082, United StatesMore by Dwight R. StollView Biographyhttp://orcid.org/0000-0002-4070-9132, and Peter J. SchoenmakersPeter J. SchoenmakersUniversity of Amsterdam, van 't Hoff Institute for Molecular Sciences, Analytical-Chemistry Group, Science Park 904, 1098 XH Amsterdam, The NetherlandsMore by Peter J. SchoenmakersView BiographyCite this: Anal. Chem. 2019, 91, 1, 240–263Publication Date (Web):November 1, 2018Publication History Published online1 November 2018Published inissue 2 January 2019https://pubs.acs.org/doi/10.1021/acs.analchem.8b04841https://doi.org/10.1021/acs.analchem.8b04841review-articleACS PublicationsCopyright © 2018 American Chemical Society. This publication is licensed under CC-BY-NC-ND. This publication is Open Access under the license indicated. Learn MoreArticle Views13313Altmetric-Citations247LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (8 MB) Get e-AlertscloseSUBJECTS:Biopolymers,Chromatography,Peptides and proteins,Size exclusion chromatography,Solvents Get e-Alerts