神经保护
纽恩
神经发生
川芎嗪
神经科学
神经再生
冲程(发动机)
医学
双皮质醇
齿状回
药理学
生物
海马体
内科学
病理
免疫组织化学
工程类
替代医学
机械工程
作者
Liangmiao Wu,Jie Cao,Ning Li,Haiyun Chen,Wei Liu,Gaoxiao Zhang,Yu Liu,Yuqiang Wang,Yewei Sun,Zaijun Zhang
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2019-06-12
卷期号:30 (9): 658-663
被引量:8
标识
DOI:10.1097/wnr.0000000000001256
摘要
Neuronal death is among the deleterious pathological changes that occur after cerebral ischemia and can lead to transient or permanent neurological deficits. The tetramethylpyrazine analog T-006 has been shown to be a multifunctional neuroprotective agent; however, its neuroprotective effect and mechanism of action have not been studied in ischemic stroke model rats. This study investigated the neuroprotective effects of T-006 in rat stroke model using a battery of behavioral and molecular biological tests. Results indicated that T-006 treatment significantly improved neurological function and behavior. Double immunofluorescence staining showed that T-006 visibly improved the number of NeuN+/BrdU+, Nestin+/BrdU+, and DCX+/BrdU+ cells and induced neuronal regeneration. Western blot analyses indicated that T-006 upregulated neurogenesis-related protein expression of postsynaptic density protein 95, brain-derived neurotrophic factor, synaptophysin, and myelin basic protein. Collectively, these data suggest that T-006 stimulated neurogenesis in rats with middle cerebral artery occlusion and restored neurological functions.
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