化学
糖基化
糖苷
组合化学
有机化学
立体化学
生物化学
作者
Jing Fang,Jing Zeng,Jiuchang Sun,Shuxin Zhang,Xiong Xiao,Zimin Lü,Lingkui Meng,Qian Wan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-06-24
卷期号:21 (16): 6213-6216
被引量:16
标识
DOI:10.1021/acs.orglett.9b02004
摘要
Murucoidins IV and V, two bioactive resin glycosides with complex yet similar structures isolated from the morning glory family, were synthesized in a convergent manner. All of the glycosylations in these syntheses including the key [3 + 2] coupling were achieved by our recently developed interrupted Pummerer reaction mediated (IPRm) glycosylations. The broad functional group compatibility of IPRm glycosylation allowed us to employ a latent-active concept and a single-pot transient protection–glycosylation–deprotection strategy which significantly improved the global synthetic efficiency.
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