亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Structural connectivity and weight loss in children with obesity: a study of the “connectobese”

中间性中心性 连接体 聚类系数 连接组学 认知 磁共振弥散成像 医学 神经科学 心理学 部分各向异性 发展心理学 中心性 聚类分析 磁共振成像 功能连接 机器学习 放射科 计算机科学 组合数学 数学
作者
Mireille Augustijn,Maria A. Di Biase,Andrew Zalesky,Lore Van Acker,Ann De Guchtenaere,Eva D’Hondt,Matthieu Lenoir,Frederik Deconinck,Karen Caeyenberghs
出处
期刊:International Journal of Obesity [Springer Nature]
卷期号:43 (11): 2309-2321 被引量:12
标识
DOI:10.1038/s41366-019-0380-6
摘要

Previous studies suggest that obesity (OB) is associated with disrupted brain network organization; however, it remains unclear whether these differences already exist during childhood. Moreover, it should be investigated whether deviant network organization may be susceptible to treatment. Here, we compared the structural connectomes of children with OB with age-matched healthy weight (HW) controls (aged 7–11 years). In addition, we examined the effect of a multidisciplinary treatment program, consisting of diet restriction, cognitive behavioral therapy, and physical activity for children with OB on brain network organization. After stringent quality assessment criteria, 40 (18 OB, 22 HW) data sets of the total sample of 51 participants (25 OB, 26 HW) were included in further analyses. For all participants, anthropometric measurements were administered twice, with a 5-month interval between pre- and post tests. Pre- and post T1- and diffusion-weighted imaging scans were also acquired and analyzed using a graph-theoretical approach and network-based statistics. Global network analyses revealed a significantly increased normalized clustering coefficient and small-worldness in children with OB compared with HW controls. In addition, regional analyses revealed increased betweenness centrality, reduced clustering coefficient, and increased structural network strength in children with OB, mainly in the motor cortex and reward network. Importantly, children with OB lost a considerable amount of their body mass after the treatment; however, no changes were observed in the organization of their brain networks. This is the first study showing disrupted structural connectomes of children with OB, especially in the motor and reward network. These results provide new insights into the pathophysiology underlying childhood obesity. The treatment did result in a significant weight loss, which was however not associated with alterations in the brain networks. These findings call for larger samples to examine the impact of short-term and long-term weight loss (treatment) on children's brain network organization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Perry完成签到,获得积分10
1分钟前
大个应助cc采纳,获得10
1分钟前
柯语雪完成签到 ,获得积分10
1分钟前
1分钟前
cc发布了新的文献求助10
2分钟前
神经蛙完成签到,获得积分10
2分钟前
甜美的问蕊完成签到 ,获得积分10
3分钟前
新世界的蜗牛完成签到,获得积分10
3分钟前
4分钟前
4分钟前
祖之微笑发布了新的文献求助200
4分钟前
FSYHantis完成签到,获得积分10
5分钟前
宋丽薇完成签到,获得积分10
6分钟前
上官若男应助cc采纳,获得10
6分钟前
缪静柏发布了新的文献求助30
7分钟前
祖之微笑完成签到,获得积分10
7分钟前
7分钟前
六月初八夜完成签到,获得积分10
7分钟前
cc发布了新的文献求助10
7分钟前
7分钟前
李健的粉丝团团长应助1577采纳,获得10
7分钟前
喵喵完成签到 ,获得积分10
7分钟前
猪皮恶人发布了新的文献求助10
7分钟前
8分钟前
祖之微笑发布了新的文献求助10
8分钟前
8分钟前
1577发布了新的文献求助10
8分钟前
8分钟前
缪静柏发布了新的文献求助10
8分钟前
1577完成签到,获得积分10
8分钟前
xiaogang127完成签到 ,获得积分10
9分钟前
9分钟前
栗子发布了新的文献求助10
9分钟前
天天快乐应助栗子采纳,获得10
9分钟前
皮老师发布了新的文献求助20
10分钟前
皮老师完成签到,获得积分10
10分钟前
打打应助savagecas采纳,获得10
10分钟前
10分钟前
savagecas发布了新的文献求助10
10分钟前
赘婿应助Xulun采纳,获得10
11分钟前
高分求助中
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
Дружба 友好报 (1957-1958) 1000
Diamonds: Properties, Synthesis and Applications 1000
The Data Economy: Tools and Applications 1000
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 700
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufe 700
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3099758
求助须知:如何正确求助?哪些是违规求助? 2751215
关于积分的说明 7612024
捐赠科研通 2403006
什么是DOI,文献DOI怎么找? 1275089
科研通“疑难数据库(出版商)”最低求助积分说明 616238
版权声明 599033