Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark Address: Section of Surgical Pathophysiology, Rigshospitalet, 7621, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Tel.: +45 3545 4774; fax: +45 3545 6543. E-mail address: [email protected] (H. Kehlet). Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.