内化
纳米片
材料科学
纳米颗粒
自噬
PI3K/AKT/mTOR通路
生物物理学
细胞
细胞生物学
纳米技术
受体
信号转导
生物
生物化学
细胞凋亡
作者
Xiaofei Zhou,Jianbo Jia,Zhen Luo,Gaoxing Su,Tongtao Yue,Bing Yan
标识
DOI:10.1021/acsami.8b21886
摘要
The ability of nanoparticles to induce adverse consequences in human cells relies on their physical shapes. In this aspect, how two-dimensional nanoparticles differ from three-dimensional nanoparticles is not well-known. To elucidate this difference, combined experimental and theoretical approaches are employed to compare MoS2 nanosheets with 5-layer and 40-layer thicknesses for their cellular effects and the associated molecular events. At a concentration as defined by the nanosheet surface areas (10 cm2/mL), 40-layer nanosheets are internalized by cells, whereas 5-layer nanosheets mostly bind to the cell surface without internalization. Although they alter different autophagy-related genes, a common mechanism is that they both perturb cell surface protein amyloid precursor proteins and activate the mTOR signaling pathway. Our findings prove that the perturbation of cellular function without nanoparticle internalization has significant nanomedicinal and nanotoxicological significances.
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