Differential evolution (DE) is an effective evolutionary algorithm for global optimization, and widely applied to solve different optimization problems. However, the convergence speed of DE will be slower in the later stage of the evolution and it is more likely to get stuck at a local optimum. Moreover, the performance of DE is sensitive to its mutation strategies and control parameters. Therefore, a self-adaptive mutation differential evolution algorithm based on particle swarm optimization (DEPSO) is proposed to improve the optimization performance of DE. DEPSO can effectively utilize an improved DE/rand/1 mutation strategy with stronger global exploration ability and PSO mutation strategy with higher convergence ability. As a result, the population diversity can be maintained well in the early stage of the evolution, and the faster convergence speed can be obtained in the later stage of the evolution. The performance of the proposed DEPSO is evaluated on 30-dimensional and 100-dimensional functions. The experimental results indicate that DEPSO can significantly improve the global convergence performance of the conventional DE and thus avoid premature convergence, and its average performance is better than those of the conventional DE, PSO and the compared algorithms. Moreover, DEPSO is applied to solve arrival flights scheduling and the optimization results show that it can optimize the sequence and decrease the delay time.